Your Digest for Monday, Apr 22, 2024 02:59 PM


Phase I - double digits (<100)
Phase II - Triple digits (<300)
Phase III - quadruple digits, also C being the 3rd letter of the alphabet, phase III trials 'compare' efficacy -> RCTs. (<3000)
3. Phamacokinetic testing to determine ADME characteristics (absorption, distribution, metabolism and elimination)
Phase 3 = 1000-3000 to confirm effectiveness, monitor side effects and compare with other treatments. (⭐therapeutic confirmation - Randomized controlled trials; efficacy, safety)

[!INFO] Mmemonic: Bag of flowers
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Other causes of subtotal villous atrophy

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Source
Pharmacological efficacy (also called Intrinsic efficacy) is


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[[2018-OCT-BSQ#Pulmonary vascular resistance]]


Pathophysiology of NAFLD

Insulin resistance is the key prerequisite for NAFLD.

  1. Dyslipidaemia (Low HDL and high TGL)