Phase I - double digits (<100)
Phase II - Triple digits (<300)
Phase III - quadruple digits, also C being the 3rd letter of the alphabet, phase III trials 'compare' efficacy -> RCTs. (<3000)
3. Phamacokinetic testing to determine ADME characteristics (absorption, distribution, metabolism and elimination)
Phase 3 = 1000-3000 to confirm effectiveness, monitor side effects and compare with other treatments. (⭐therapeutic confirmation - Randomized controlled trials; efficacy, safety)
[!INFO] Mmemonic: Bag of flowers
⭐
⭐
Source
Pharmacological efficacy (also called Intrinsic efficacy) is
[[2018-OCT-BSQ#Pulmonary vascular resistance]]
Insulin resistance is the key prerequisite for NAFLD.